2006 Cadillac CTS
5 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| CTS | 16 | 25 | 19 | Regular Gasoline | Rear-Wheel Drive | 3.6L 6-cyl | Automatic (S5) |
| CTS | 15 | 25 | 19 | Regular Gasoline | Rear-Wheel Drive | 2.8L 6-cyl | Manual 6-spd |
| CTS | 16 | 24 | 19 | Regular Gasoline | Rear-Wheel Drive | 2.8L 6-cyl | Automatic (S5) |
| CTS | 15 | 24 | 18 | Regular Gasoline | Rear-Wheel Drive | 3.6L 6-cyl | Manual 6-spd |
| CTS-V | 14 | 23 | 17 | Premium Gasoline | Rear-Wheel Drive | 6L 8-cyl | Manual 6-spd |