2000 Ford E250 Econoline
3 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| E250 Econoline 2WD | 12 | 16 | 14 | Regular Gasoline | Rear-Wheel Drive | 4.2L 6-cyl | Automatic 4-spd |
| E250 Econoline 2WD | 12 | 17 | 13 | Regular Gasoline | Rear-Wheel Drive | 5.4L 8-cyl | Automatic 4-spd |
| E250 Econoline 2WD CNG | 11 | 14 | 12 | Natural Gas | Rear-Wheel Drive | 5.4L 8-cyl | Automatic 4-spd |