2010 Lexus GS
4 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| GS 350 | 19 | 26 | 22 | Premium Gasoline | Rear-Wheel Drive | 3.5L 6-cyl | Automatic (S6) |
| GS 350 AWD | 18 | 25 | 20 | Premium Gasoline | All-Wheel Drive | 3.5L 6-cyl | Automatic (S6) |
| GS 450h Hybrid | 22 | 25 | 23 | Premium Gasoline | Rear-Wheel Drive | 3.5L 6-cyl | Automatic (AV-S6) |
| GS 460 | 17 | 24 | 20 | Premium Gasoline | Rear-Wheel Drive | 4.6L 8-cyl | Automatic (S8) |