2006 Lexus IS
4 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| IS 250 | 18 | 26 | 21 | Premium Gasoline | Rear-Wheel Drive | 2.5L 6-cyl | Manual 6-spd |
| IS 250 | 21 | 29 | 24 | Premium Gasoline | Rear-Wheel Drive | 2.5L 6-cyl | Automatic (S6) |
| IS 250 AWD | 20 | 26 | 22 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 2.5L 6-cyl | Automatic (S6) |
| IS 350 | 19 | 26 | 21 | Premium Gasoline | Rear-Wheel Drive | 3.5L 6-cyl | Automatic (S6) |