2021 Lexus IS
4 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| IS 300 | 21 | 31 | 25 | Premium Gasoline | Rear-Wheel Drive | 2L 4-cyl Turbo | Automatic (S8) |
| IS 300 AWD | 19 | 26 | 22 | Premium Gasoline | All-Wheel Drive | 3.5L 6-cyl | Automatic (S6) |
| IS 350 | 20 | 28 | 23 | Premium Gasoline | Rear-Wheel Drive | 3.5L 6-cyl | Automatic (S8) |
| IS 350 AWD | 19 | 26 | 22 | Premium Gasoline | All-Wheel Drive | 3.5L 6-cyl | Automatic (S6) |