2006 Lexus RX
6 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| RX 330 2WD | 17 | 23 | 20 | Premium Gasoline | Front-Wheel Drive | 3.3L 6-cyl | Automatic 5-spd |
| RX 330 2WD | 17 | 23 | 19 | Premium Gasoline | Front-Wheel Drive | 3.3L 6-cyl | Automatic (S5) |
| RX 330 4WD | 16 | 22 | 19 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 3.3L 6-cyl | Automatic 5-spd |
| RX 330 4WD | 16 | 22 | 18 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 3.3L 6-cyl | Automatic (S5) |
| RX 400h 2WD Hybrid | 28 | 25 | 27 | Regular Gasoline | Front-Wheel Drive | 3.3L 6-cyl | Automatic (variable gear ratios) |
| RX 400h 4WD Hybrid | 27 | 25 | 26 | Regular Gasoline | 4-Wheel or All-Wheel Drive | 3.3L 6-cyl | Automatic (variable gear ratios) |