2008 Lexus RX
6 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| RX 350 2WD | 18 | 23 | 20 | Premium Gasoline | Front-Wheel Drive | 3.5L 6-cyl | Automatic (S5) |
| RX 350 2WD | 18 | 23 | 20 | Premium Gasoline | Front-Wheel Drive | 3.5L 6-cyl | Automatic 5-spd |
| RX 350 4WD | 17 | 22 | 19 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 3.5L 6-cyl | Automatic 5-spd |
| RX 350 4WD | 17 | 22 | 19 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 3.5L 6-cyl | Automatic (S5) |
| RX 400h 2WD Hybrid | 27 | 24 | 25 | Premium Gasoline | Front-Wheel Drive | 3.3L 6-cyl | Automatic (variable gear ratios) |
| RX 400h 4WD Hybrid | 26 | 24 | 25 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 3.3L 6-cyl | Automatic (variable gear ratios) |