2010 Lexus RX
4 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| RX 350 2WD | 18 | 25 | 21 | Premium Gasoline | Front-Wheel Drive | 3.5L 6-cyl | Automatic (S6) |
| RX 350 AWD | 18 | 24 | 20 | Premium Gasoline | All-Wheel Drive | 3.5L 6-cyl | Automatic (S6) |
| RX 450h Hybrid | 32 | 28 | 30 | Premium Gasoline | Front-Wheel Drive | 3.5L 6-cyl | Automatic (AV-S6) |
| RX 450h AWD Hybrid | 30 | 28 | 29 | Premium Gasoline | All-Wheel Drive | 3.5L 6-cyl | Automatic (AV-S6) |