2022 Lexus RX
6 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| RX 350 | 20 | 27 | 23 | Regular Gasoline | Front-Wheel Drive | 3.5L 6-cyl | Automatic (S8) |
| RX 350 AWD | 19 | 26 | 22 | Regular Gasoline | All-Wheel Drive | 3.5L 6-cyl | Automatic (S8) |
| RX 350 L | 19 | 26 | 22 | Regular Gasoline | Front-Wheel Drive | 3.5L 6-cyl | Automatic (S8) |
| RX 350 L AWD | 18 | 25 | 21 | Regular Gasoline | All-Wheel Drive | 3.5L 6-cyl | Automatic (S8) |
| RX 450h AWD Hybrid | 31 | 28 | 30 | Premium Gasoline | All-Wheel Drive | 3.5L 6-cyl | Automatic (AV-S6) |
| RX 450h L AWD Hybrid | 29 | 28 | 29 | Premium Gasoline | All-Wheel Drive | 3.5L 6-cyl | Automatic (AV-S6) |