2006 Mercedes-Benz C-Class
8 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| C230 | 19 | 27 | 22 | Premium Gasoline | Rear-Wheel Drive | 2.5L 6-cyl | Automatic 7-spd |
| C230 | 18 | 27 | 21 | Premium Gasoline | Rear-Wheel Drive | 2.5L 6-cyl | Manual 6-spd |
| C280 | 18 | 26 | 21 | Premium Gasoline | Rear-Wheel Drive | 3L 6-cyl | Automatic 7-spd |
| C280 4matic | 17 | 24 | 20 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 3L 6-cyl | Automatic 5-spd |
| C350 | 18 | 27 | 21 | Premium Gasoline | Rear-Wheel Drive | 3.5L 6-cyl | Automatic 7-spd |
| C350 | 18 | 26 | 21 | Premium Gasoline | Rear-Wheel Drive | 3.5L 6-cyl | Manual 6-spd |
| C350 4matic | 17 | 22 | 19 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 3.5L 6-cyl | Automatic 5-spd |
| C55 AMG | 15 | 20 | 17 | Premium Gasoline | Rear-Wheel Drive | 5.4L 8-cyl | Automatic (S5) |