2010 Mercedes-Benz C-Class
7 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| C300 | 18 | 26 | 21 | Premium Gasoline | Rear-Wheel Drive | 3L 6-cyl | Manual 6-spd |
| C300 | 18 | 26 | 21 | Premium Gasoline | Rear-Wheel Drive | 3L 6-cyl | Automatic 7-spd |
| C300 | 18 | 26 | 21 | Premium Gasoline | Rear-Wheel Drive | 3.5L 6-cyl | Automatic 7-spd |
| C300 4matic | 18 | 25 | 20 | Premium Gasoline | 4-Wheel Drive | 3L 6-cyl | Automatic 7-spd |
| C300 4matic | 17 | 24 | 20 | Premium Gasoline | 4-Wheel Drive | 3.5L 6-cyl | Automatic 7-spd |
| C350 | 17 | 25 | 20 | Premium Gasoline | Rear-Wheel Drive | 3.5L 6-cyl | Automatic 7-spd |
| C63 AMG | 12 | 19 | 15 | Premium Gasoline | Rear-Wheel Drive | 6.3L 8-cyl | Automatic 7-spd |