2021 Mercedes-Benz CLS-Class
3 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| AMG CLS53 4matic Plus Hybrid | 21 | 26 | 23 | Premium Gasoline | 4-Wheel Drive | 3L 6-cyl | Automatic 9-spd |
| CLS450 Hybrid | 23 | 30 | 26 | Premium Gasoline | Rear-Wheel Drive | 3L 6-cyl Turbo | Automatic 9-spd |
| CLS450 4matic Hybrid | 22 | 29 | 25 | Premium Gasoline | 4-Wheel Drive | 3L 6-cyl Turbo | Automatic 9-spd |