2001 Mercedes-Benz E-Class
7 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| E320 | 18 | 26 | 21 | Premium Gasoline | Rear-Wheel Drive | 3.2L 6-cyl | Automatic 5-spd |
| E320 (Wagon) | 17 | 25 | 20 | Premium Gasoline | Rear-Wheel Drive | 3.2L 6-cyl | Automatic 5-spd |
| E320 4Matic | 18 | 24 | 20 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 3.2L 6-cyl | Automatic 5-spd |
| E320 4Matic (Wagon) | 17 | 25 | 20 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 3.2L 6-cyl | Automatic 5-spd |
| E430 | 16 | 23 | 19 | Premium Gasoline | Rear-Wheel Drive | 4.3L 8-cyl | Automatic 5-spd |
| E430 4Matic | 16 | 21 | 18 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 4.3L 8-cyl | Automatic 5-spd |
| E55 AMG | 15 | 22 | 18 | Premium Gasoline | Rear-Wheel Drive | 5.4L 8-cyl | Automatic 5-spd |