2006 Mercedes-Benz E-Class
10 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| E320 Cdi | 23 | 33 | 27 | Diesel | Rear-Wheel Drive | 3.2L 6-cyl Turbo | Automatic 5-spd |
| E350 | 17 | 25 | 20 | Premium Gasoline | Rear-Wheel Drive | 3.5L 6-cyl | Automatic 7-spd |
| E350 (wagon) | 16 | 24 | 19 | Premium Gasoline | Rear-Wheel Drive | 3.5L 6-cyl | Automatic 7-spd |
| E350 4matic | 16 | 23 | 19 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 3.5L 6-cyl | Automatic 5-spd |
| E350 4matic (wagon) | 16 | 22 | 18 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 3.5L 6-cyl | Automatic 5-spd |
| E500 | 15 | 23 | 18 | Premium Gasoline | Rear-Wheel Drive | 5L 8-cyl | Automatic 7-spd |
| E500 4matic | 14 | 19 | 16 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 5L 8-cyl | Automatic 5-spd |
| E500 4matic (wagon) | 14 | 18 | 16 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 5L 8-cyl | Automatic 5-spd |
| E55 AMG | 13 | 19 | 16 | Premium Gasoline | Rear-Wheel Drive | 5.4L 8-cyl Supercharged | Automatic (S5) |
| E55 AMG (wagon) | 13 | 20 | 15 | Premium Gasoline | Rear-Wheel Drive | 5.4L 8-cyl Supercharged | Automatic (S5) |