2008 Mercedes-Benz E-Class
8 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| E320 Bluetec | 23 | 32 | 26 | Diesel | Rear-Wheel Drive | 3L 6-cyl Turbo | Automatic 7-spd |
| E350 | 17 | 24 | 19 | Premium Gasoline | Rear-Wheel Drive | 3.5L 6-cyl | Automatic 7-spd |
| E350 4matic | 16 | 22 | 18 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 3.5L 6-cyl | Automatic 5-spd |
| E350 4matic (wagon) | 16 | 21 | 18 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 3.5L 6-cyl | Automatic 5-spd |
| E550 | 15 | 22 | 17 | Premium Gasoline | Rear-Wheel Drive | 5.5L 8-cyl | Automatic 7-spd |
| E550 4matic | 13 | 19 | 16 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 5.5L 8-cyl | Automatic 7-spd |
| E63 AMG | 12 | 19 | 15 | Premium Gasoline | Rear-Wheel Drive | 6.2L 8-cyl | Automatic (S7) |
| E63 AMG (wagon) | 12 | 18 | 14 | Premium Gasoline | Rear-Wheel Drive | 6.2L 8-cyl | Automatic (S7) |