2010 Mercedes-Benz E-Class
7 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| E350 | 18 | 26 | 21 | Premium Gasoline | Rear-Wheel Drive | 3.5L 6-cyl | Automatic 7-spd |
| E350 4matic | 17 | 24 | 19 | Premium Gasoline | 4-Wheel Drive | 3.5L 6-cyl | Automatic 7-spd |
| E350 Coupe | 17 | 26 | 20 | Premium Gasoline | Rear-Wheel Drive | 3.5L 6-cyl | Automatic 7-spd |
| E550 | 16 | 24 | 18 | Premium Gasoline | Rear-Wheel Drive | 5.5L 8-cyl | Automatic 7-spd |
| E550 4matic | 15 | 23 | 18 | Premium Gasoline | 4-Wheel Drive | 5.5L 8-cyl | Automatic 7-spd |
| E550 Coupe | 15 | 23 | 18 | Premium Gasoline | Rear-Wheel Drive | 5.5L 8-cyl | Automatic 7-spd |
| E63 AMG | 13 | 20 | 15 | Premium Gasoline | Rear-Wheel Drive | 6.3L 8-cyl | Automatic 7-spd |