2026 Mercedes-Benz E-Class
6 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| AMG E53 Hybrid 4matic Plus PHEV | 22 | 27 | 24 | Premium Gasoline | All-Wheel Drive | 3L 6-cyl Turbo | Automatic 9-spd |
| AMG E53 Hybrid 4matic Plus (station wagon) PHEV | 21 | 25 | 22 | Premium Gasoline | All-Wheel Drive | 3L 6-cyl Turbo | Automatic 9-spd |
| E350 Hybrid | 25 | 33 | 28 | Premium Gasoline | Rear-Wheel Drive | 2L 4-cyl Turbo | Automatic 9-spd |
| E350 4matic Hybrid | 24 | 33 | 27 | Premium Gasoline | All-Wheel Drive | 2L 4-cyl Turbo | Automatic 9-spd |
| E450 4matic Hybrid | 22 | 31 | 25 | Premium Gasoline | All-Wheel Drive | 3L 6-cyl Turbo Supercharged | Automatic 9-spd |
| E450 4matic All-Terrain (wagon) Hybrid | 22 | 31 | 25 | Premium Gasoline | All-Wheel Drive | 3L 6-cyl Turbo Supercharged | Automatic 9-spd |
This model includes plug-in hybrid (PHEV) configurations. MPG figures shown are for gasoline-only operation.