2025 Mercedes-Benz GLS-Class
4 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| AMG GLS63 4matic Plus Hybrid | 14 | 18 | 15 | Premium Gasoline | All-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| GLS450 4matic Hybrid | 19 | 24 | 21 | Premium Gasoline | All-Wheel Drive | 3L 6-cyl Turbo Supercharged | Automatic 9-spd |
| GLS580 4matic Hybrid | 14 | 19 | 16 | Premium Gasoline | All-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| GLS600 4matic Maybach Hybrid | 13 | 18 | 15 | Premium Gasoline | All-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |