1999 Mercedes-Benz S-Class
5 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| S320 | 15 | 22 | 18 | Premium Gasoline | Rear-Wheel Drive | 3.2L 6-cyl | Automatic 5-spd |
| S320 | 15 | 22 | 18 | Premium Gasoline | Rear-Wheel Drive | 3.2L 6-cyl | Automatic 5-spd |
| S420 | 14 | 20 | 16 | Premium Gasoline | Rear-Wheel Drive | 4.2L 8-cyl | Automatic 5-spd |
| S500 | 13 | 20 | 16 | Premium Gasoline | Rear-Wheel Drive | 5L 8-cyl | Automatic 5-spd |
| S600 | 11 | 17 | 13 | Premium Gasoline | Rear-Wheel Drive | 6L 12-cyl | Automatic 5-spd |