2001 Mercedes-Benz S-Class
4 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| S430 | 16 | 23 | 18 | Premium Gasoline | Rear-Wheel Drive | 4.3L 8-cyl | Automatic 5-spd |
| S500 | 14 | 21 | 17 | Premium Gasoline | Rear-Wheel Drive | 5L 8-cyl | Automatic 5-spd |
| S55 AMG | 14 | 20 | 17 | Premium Gasoline | Rear-Wheel Drive | 5.4L 8-cyl | Automatic 5-spd |
| S600 | 14 | 21 | 16 | Premium Gasoline | Rear-Wheel Drive | 5.8L 12-cyl | Automatic 5-spd |