2003 Mercedes-Benz S-Class
6 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| S430 | 15 | 22 | 18 | Premium Gasoline | Rear-Wheel Drive | 4.3L 8-cyl | Automatic 5-spd |
| S430 4matic | 15 | 20 | 17 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 4.3L 8-cyl | Automatic 5-spd |
| S500 | 14 | 20 | 16 | Premium Gasoline | Rear-Wheel Drive | 5L 8-cyl | Automatic 5-spd |
| S500 4matic | 14 | 19 | 16 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 5L 8-cyl | Automatic 5-spd |
| S55 AMG | 13 | 20 | 15 | Premium Gasoline | Rear-Wheel Drive | 5L 8-cyl Supercharged | Automatic 5-spd |
| S600 | 12 | 17 | 14 | Premium Gasoline | Rear-Wheel Drive | 5.5L 12-cyl Turbo | Automatic 5-spd |