2006 Mercedes-Benz S-Class
8 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| S350 | 16 | 23 | 18 | Premium Gasoline | Rear-Wheel Drive | 3.7L 6-cyl | Automatic 5-spd |
| S430 | 16 | 24 | 19 | Premium Gasoline | Rear-Wheel Drive | 4.3L 8-cyl | Automatic 7-spd |
| S430 4matic | 15 | 21 | 17 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 4.3L 8-cyl | Automatic 5-spd |
| S500 | 14 | 22 | 17 | Premium Gasoline | Rear-Wheel Drive | 5L 8-cyl | Automatic 7-spd |
| S500 4matic | 14 | 20 | 16 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 5L 8-cyl | Automatic 5-spd |
| S55 AMG | 13 | 20 | 16 | Premium Gasoline | Rear-Wheel Drive | 5.4L 8-cyl Supercharged | Automatic (S5) |
| S600 | 11 | 17 | 13 | Premium Gasoline | Rear-Wheel Drive | 5.5L 12-cyl Turbo | Automatic 5-spd |
| S65 AMG | 11 | 18 | 14 | Premium Gasoline | Rear-Wheel Drive | 6L 12-cyl Turbo | Automatic (S5) |