2007 Mercedes-Benz S-Class
4 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| S550 | 14 | 22 | 17 | Premium Gasoline | Rear-Wheel Drive | 5.5L 8-cyl | Automatic 7-spd |
| S550 4matic | 14 | 21 | 16 | Premium Gasoline | 4-Wheel or All-Wheel Drive | 5.5L 8-cyl | Automatic 7-spd |
| S600 | 11 | 17 | 13 | Premium Gasoline | Rear-Wheel Drive | 5.5L 12-cyl Turbo | Automatic 5-spd |
| S65 AMG | 11 | 18 | 14 | Premium Gasoline | Rear-Wheel Drive | 6L 12-cyl Turbo | Automatic (S5) |