2017 Mercedes-Benz S-Class
12 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| AMG S63 4matic | 15 | 23 | 18 | Premium Gasoline | 4-Wheel Drive | 5.5L 8-cyl Turbo | Automatic 7-spd |
| AMG S63 4matic Convertible | 14 | 22 | 17 | Premium Gasoline | 4-Wheel Drive | 5.5L 8-cyl Turbo | Automatic 7-spd |
| AMG S63 4matic Coupe | 15 | 23 | 18 | Premium Gasoline | 4-Wheel Drive | 5.5L 8-cyl Turbo | Automatic 7-spd |
| AMG S65 | 13 | 22 | 16 | Premium Gasoline | Rear-Wheel Drive | 6L 12-cyl Turbo | Automatic 7-spd |
| S550 | 18 | 26 | 21 | Premium Gasoline | Rear-Wheel Drive | 4.7L 8-cyl Turbo | Automatic 9-spd |
| S550 4matic | 16 | 25 | 20 | Premium Gasoline | 4-Wheel Drive | 4.7L 8-cyl Turbo | Automatic 9-spd |
| S550 4matic Coupe | 17 | 25 | 20 | Premium Gasoline | 4-Wheel Drive | 4.7L 8-cyl Turbo | Automatic 9-spd |
| S550 Convertible | 17 | 25 | 20 | Premium Gasoline | Rear-Wheel Drive | 4.7L 8-cyl Turbo | Automatic 9-spd |
| S550e PHEV | 24 | 30 | 26 | Premium Gasoline | Rear-Wheel Drive | 3L 6-cyl Turbo | Automatic 7-spd |
| S600 | 13 | 22 | 16 | Premium Gasoline | Rear-Wheel Drive | 6L 12-cyl Turbo | Automatic 7-spd |
| S65 AMG Convertible | 14 | 21 | 16 | Premium Gasoline | Rear-Wheel Drive | 6L 12-cyl Turbo | Automatic 7-spd |
| S65 AMG Coupe | 13 | 21 | 16 | Premium Gasoline | Rear-Wheel Drive | 6L 12-cyl Turbo | Automatic 7-spd |
This model includes plug-in hybrid (PHEV) configurations. MPG figures shown are for gasoline-only operation.