2020 Mercedes-Benz S-Class
13 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| AMG S63 4matic Plus | 17 | 26 | 20 | Premium Gasoline | 4-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| AMG S63 4matic Plus Convertible | 15 | 24 | 18 | Premium Gasoline | 4-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| AMG S63 4matic Plus Coupe | 17 | 27 | 20 | Premium Gasoline | 4-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| AMG S65 | 13 | 22 | 16 | Premium Gasoline | Rear-Wheel Drive | 6L 12-cyl Turbo | Automatic 7-spd |
| Maybach S650 | 13 | 21 | 16 | Premium Gasoline | Rear-Wheel Drive | 6L 12-cyl Turbo | Automatic 7-spd |
| S450 | 19 | 28 | 22 | Premium Gasoline | Rear-Wheel Drive | 3L 6-cyl Turbo | Automatic 9-spd |
| S450 4matic | 18 | 28 | 22 | Premium Gasoline | 4-Wheel Drive | 3L 6-cyl Turbo | Automatic 9-spd |
| S560 | 17 | 27 | 21 | Premium Gasoline | Rear-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| S560 4matic | 17 | 27 | 21 | Premium Gasoline | 4-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| S560 4matic Coupe | 17 | 26 | 20 | Premium Gasoline | 4-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| S560 4matic Maybach | 16 | 25 | 19 | Premium Gasoline | 4-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| S560 Convertible | 17 | 26 | 20 | Premium Gasoline | Rear-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| S560e PHEV | 21 | 26 | 23 | Premium Gasoline | Rear-Wheel Drive | 3L 6-cyl Turbo | Automatic 9-spd |
This model includes plug-in hybrid (PHEV) configurations. MPG figures shown are for gasoline-only operation.