2021 Mercedes-Benz S-Class
7 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| AMG S63 4matic Plus Convertible | 14 | 24 | 17 | Premium Gasoline | 4-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| AMG S63 4matic Plus Coupe | 16 | 26 | 19 | Premium Gasoline | 4-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| S500 4matic Hybrid | 20 | 29 | 24 | Premium Gasoline | 4-Wheel Drive | 3L 6-cyl | Automatic 9-spd |
| S560 4matic Coupe | 16 | 26 | 20 | Premium Gasoline | 4-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| S560 Convertible | 16 | 26 | 20 | Premium Gasoline | Rear-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| S580 4matic Hybrid | 17 | 25 | 20 | Premium Gasoline | 4-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| S580 4matic Maybach Hybrid | 16 | 24 | 19 | Premium Gasoline | 4-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |