2022 Mercedes-Benz S-Class
4 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| Maybach S680 4matic | 12 | 21 | 15 | Premium Gasoline | All-Wheel Drive | 6L 12-cyl Turbo | Automatic 9-spd |
| S500 4matic Hybrid | 21 | 30 | 24 | Premium Gasoline | All-Wheel Drive | 3L 6-cyl | Automatic 9-spd |
| S580 4matic Hybrid | 16 | 25 | 19 | Premium Gasoline | All-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| S580 4matic Maybach Hybrid | 15 | 24 | 18 | Premium Gasoline | All-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |