2025 Mercedes-Benz S-Class
6 configurations — EPA fuel economy ratings
| Trim / Variant | City MPG | Hwy MPG | Combined MPG | Fuel | Drive | Engine | Transmission |
|---|---|---|---|---|---|---|---|
| AMG S63 E Performance PHEV | 15 | 23 | 18 | Premium Gasoline | All-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| Maybach S680 4matic | 12 | 20 | 15 | Premium Gasoline | All-Wheel Drive | 6L 12-cyl Turbo | Automatic 9-spd |
| S500 4matic Hybrid | 21 | 31 | 24 | Premium Gasoline | All-Wheel Drive | 3L 6-cyl Turbo Supercharged | Automatic 9-spd |
| S580 4matic Hybrid | 17 | 25 | 20 | Premium Gasoline | All-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| S580 4matic Maybach Hybrid | 16 | 27 | 20 | Premium Gasoline | All-Wheel Drive | 4L 8-cyl Turbo | Automatic 9-spd |
| S580e 4matic PHEV | 20 | 29 | 23 | Premium Gasoline | All-Wheel Drive | 3L 6-cyl Turbo | Automatic 9-spd |
This model includes plug-in hybrid (PHEV) configurations. MPG figures shown are for gasoline-only operation.